Query: jax_ensembl_strand_annot jax_mgd_entrez-gene-strand_annot jax_mgd_strand_annot ncbi_refseq_orientation_annot ncbi_refseq_xm_acc ncbi_refseq_xp_acc affymetrix_netaffyx_affyprobe_uid affymetrix_netaffyx_chip_annot ebi_ipi_database_entry_annot ebi_ipi_embl-genbank-ddbj-prot_xref ebi_ipi_ensembl-acc_xref ebi_ipi_entrez-gene-uid_xref ebi_ipi_entrez-officialsymbol_xref ebi_ipi_jax-marker-acc_xref ebi_ipi_jax-symbol_xref ebi_ipi_multi-prot_xref ebi_ipi_prot_uid ebi_ipi_refseq-np-acc_xref ebi_ipi_trembl-acc_xref ebi_ipi_unigene-acc_xref ebi_ipi_uniparc-acc_xref jax_ensembl_chr_annot jax_ensembl_gene_acc jax_ensembl_physical-end_annot jax_ensembl_physical-start_annot jax_mgd_aliassymbol_annot jax_mgd_build_annot jax_mgd_chr_annot jax_mgd_cM_annot jax_mgd_entrez-gene-chr_annot jax_mgd_entrez-gene-physical-end-Bp_annot jax_mgd_entrez-gene-physical-start-Bp_annot jax_mgd_entrez-gene_uid jax_mgd_gene_uid jax_mgd_marker-name_annot jax_mgd_marker-symbol_annot jax_mgd_marker-type_annot jax_mgd_marker_uid jax_mgd_phenotype_uid jax_mgd_physical-end_annot jax_mgd_physical-start_annot jax_mgd_status_annot jax_mgd_swissprot_acc ncbi_cdd_domain_annot ncbi_genbank_contig_acc ncbi_genbank_contig_uid ncbi_genbank_n_acc ncbi_genbank_n_uid ncbi_genbank_p_acc ncbi_genbank_p_uid ncbi_gene_gene_uid ncbi_gene_go-acc_xref ncbi_gene_go-evidence_annot ncbi_gene_go-term_annot ncbi_grif_function_annot ncbi_ll_aliassymbol_annot ncbi_ll_grif_annot ncbi_ll_loc-map_annot ncbi_ll_locus_uid ncbi_ll_officialname_annot ncbi_ll_officialsymbol_annot ncbi_ll_organism_annot ncbi_pubmed_literature_uid ncbi_refseq_genomicfeatureend_annot ncbi_refseq_genomicfeaturestart_annot ncbi_refseq_nc_acc ncbi_refseq_nc_uid ncbi_refseq_nm_acc ncbi_refseq_nm_uid ncbi_refseq_np_acc ncbi_refseq_np_uid ncbi_refseq_status_annot ncbi_refseq_xm_uid ncbi_refseq_xp_uid ncbi_taxonomy_taxon_uid ncbi_ug_orf_uid sib_swissprot_p_acc stanford_spd_officialsymbol_annot sis . . . . . . 1450413_at Mouse430A_2 SP BAC40023 ENSMUSP00000067132 18591 Pdgfb MGI:97528 Pdgfb P31240 IPI00132238 NP_035187 Q8R3X9 Mm.144089 UPI00000002B5 15 ENSMUSG00000000489 80067129 80048195 PDGF-B NCBI Build 34 15 46.80 15 80067129 80048195 18591 MGI:97528 withdrawn<[comma]> = Pdgfb Sis Gene MGI:97528 MP:0002124 80067129 80048195 W P31240 Platelet-derived growth factor (PDGF) NT_039621.1 51831146 AK087840 26352785 AAH53430 26352786 18591 GO:0006929 IEA substrate-bound cell migration In vitro cultures supporting the spontaneous generation of functional cardiac myocytes from murine BMCs demonstrated induced expression of PDGF]-A and -B. PDGF-AB enhances the generation of BMC-derived cardiac myocytes in mouse hearts. PDGF-B PDGF is an important effector molecule in postnatal retinal development. 15 46.8 cM 5155 platelet derived growth factor<[comma]> B polypeptide Pdgfb Mus musculus 15183724 41277642 41258708 NT_039621 63681430 NM_011057 56118300 NP_035187 40538817 PROVISIONAL 56118300 40538817 10090 Mm.144089 Q8R3X9 Pdgfb sis . . . . . . Msa.565.0_g_at Mu11KsubB . AAH23427 ENSMUSP00000000500 . . . . . . . Q8C2W1 . . . . . . Sis . . -999.00 . . . . MGI:97528 platelet derived growth factor<[comma]> B polypeptide Pdgfb . . MP:0002136 . . O . . . 28487070 BC064056 39795691 AAH64056 55930882 . GO:0008083 RCA growth factor activity . Sis PDGF-B chain transformation of NIH3T3 cells requires activation of NF-kappaB . 18591 platelet derived growth factor, B polypeptide . . 14996938 80067128 80048194 NC_000081 65543215 NM_011057 6755009 NP_035187 6755010 . 6755009 6755010 . . AAD43587 . sis . . . . . . . . . AAD43587 . . . . . . . . Q549C6 . . . . . . . . . 46.8 . . . . . . . . . MP:0002135 . . . . . . . none 342568 AAD43587 39795692 . GO:0050730 IDA regulation of peptidyl-tyrosine phosphorylation . . retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice . . . . . 14988091 . . . . . . . . . . . . . P31240 . sis . . . . . . . . . AAA40113 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002092 . . . . . . . M64848 342569 AAH23427 5453469 . GO:0030031 . cell projection biogenesis . . endothelium-restricted ablation of PDGF-B generates viable mice with variation in the density of pericytes throughout the CNS; data suggest that a reduction of the pericyte density is sufficient to cause retinopathy in mice . . . . . 11940581 . . . . . . . . . . . . . BAC40023 . sis . . . . . . . . . AAA37485 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002081 . . . . . . . M64846 342567 AAA40113 342573 . GO:0030036 . actin cytoskeleton organization and biogenesis . . results show that osteoclasts regulate osteoblasts directly and suggest that PDGF BB is a key factor in bone remodeling . . . . . 14644167 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002127 . . . . . . . BC036976 22477616 AAA37485 19484039 . GO:0008283 . cell proliferation . . Blockade transiently delays but does not prevent fibrous cap formation in ApoE null mice . . . . . 14561699 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002123 . . . . . . . BC053430 31418420 P31240 400744 . GO:0016020 . membrane . . . . . . . . 14963008 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002092 . . . . . . . M84453 342570 . 192820 . GO:0000074 . regulation of progression through cell cycle . . . . . . . . 14522834 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002127 . . . . . . . M84452 342571 . . . GO:0050875 . cellular physiological process . . . . . . . . 12176888 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002124 . . . . . . . M84450 192816 . . . GO:0005615 . extracellular space . . . . . . . . 12368212 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002136 . . . . . . . M84451 192813 . . . . . . . . . . . . . . 12528182 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002135 . . . . . . . M84449 192814 . . . . . . . . . . . . . . 2045107 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002081 . . . . . . . M64847 192818 . . . . . . . . . . . . . . 12897053 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002123 . . . . . . . BC023427 192817 . . . . . . . . . . . . . . 11076861 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . M64844 192815 . . . . . . . . . . . . . . 12477932 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . AF162784 19484038 . . . . . . . . . . . . . . 11811556 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . M84448 5453468 . . . . . . . . . . . . . . 12466851 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . M64845 342566 . . . . . . . . . . . . . . 11855867 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . M64849 . . . . . . . . . . . . . . . 12169633 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11042159 . . . . . . . . . . . . . . . sis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10349636 . . . . . . . . . . . . . . . erbB + + + + XM_196020 XP_196020 Msa.231.0_at Mouse430_2 VEGA CAI24999 ENSMUSP00000020325 13649 Egfr MGI:95294 Egfr OTTMUSP00000005387 IPI00474965 NP_031938 Q99PK1 Mm.8534 UPI000002182A 11 ENSMUSG00000020122 16808703 16646997 Wa5 NCBI Build 34 11 9.00 11 16808701 16646997 319954 MGI:2144221 withdrawn<[comma]> = Egfr 9030024J15Rik Gene MGI:1890525 MP:0002074 16808703 16646997 W Q01279 Furin-like cysteine rich region NT_039515.1 28506587 X78987 5524152 AAG24386 50804 13649 GO:0004888 IEA transmembrane receptor activity Data suggest that the binding of proteins such as cytochrome c oxidase subunit II to epidermal growth factor receptors may positively regulate survival pathways that contribute to oncogenesis. Erbb HB-EGF processed and released via PC-PLC-PKC signaling is an intermediate molecule for TGF-beta-mediated EGFR transactivation 11 A2 1956 RIKEN cDNA E230015J15 gene Egfr Mus musculus 14712229 13808700 13646996 NT_039515 63615460 NM_207655 46560581 NP_997538 46560582 VALIDATED 6681282 25071744 10090 Mm.118848 AAH23729 Egfr erbB . . . . . . 1435888_at Mu11KsubB SP AAK01081 ENSMUSP00000067132 . . . . OTTMUSP00000005386 IPI00411099 NP_997538 Q5SVE7 Mm.27299 UPI00000E8883 . . . . Erbb . . -999.00 . . . 13649 MGI:2443051 RIKEN cDNA E230015J15 gene Erbb . MGI:2144221 MP:0002073 . . O . Receptor L domain. The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain . . BC023729 26093469 AAD44149 50806 319954 GO:0005506 IPI iron ion binding . wa-2 HB-EGF induced tyrosine phosphorylation of ErbB2 and ErbB4; and to a lesser degree; of EGFR in cardiac myocytes. 11 9.0 cM 13649 epidermal growth factor receptor E230015J15Rik . 7723235 16808700 16646996 NC_000077 65527427 NM_007912 46560583 NP_031938 6681283 . 28506081 6681283 . Mm.8534 Q01279 9030024J15Rik erbB . . . . . . . . . CAI35983 ENSMUSP00000020329 . . . . Q01279 IPI00121190 . Q9EQR1 . UPI000002182B . . . . avian erythroblastic leukemia viral <[openparen]>v-erb-b<[closeparen]> oncogene homolog . . -1.00 . . . . MGI:95294 epidermal growth factor receptor E230015J15Rik . MGI:2443051 MP:0002143 . . . . . . . AK087607 22658369 CAA78249 10880776 . GO:0030139 IMP endocytic vesicle . Wa5 Involvement of the EGFR pathway in the asthma-like syndrome. . 319954 RIKEN cDNA 9030024J15 gene 9030024J15Rik . 11940581 . . . . NM_007912 6681282 NP_031938 . . . . . Mm.27299 Q9EP98 . erbB . . . . . . . . . CAI24997 . . . . . . . . Q8VHI0 . . . . . . . . . 9.0 . . . . MGI:95294 . Egfr . MGI:95294 MP:0002093 . . . . . . . AK033431 10880775 AAH23729 5524153 . GO:0005006 ISS epidermal growth factor receptor activity . AI552599 The EGF receptor can mediate the prevention of apoptosis in a hematopoietic cell line independently of both receptor-ligand binding and receptor kinase activity. . 103781 . . . 15282306 . . . . . . . . . . . . . Q99PK1 . erbB . . . . . . . . . BAB23688 . . . . . . . . Q9ERV6 . . . . . . . . . . . . . . . . . . . MP:0002095 . . . . . . . AK049452 26096143 BAB23641 458124 . GO:0050730 RCA regulation of peptidyl-tyrosine phosphorylation . wa2 ligand-independent activation of the epidermal growth factor receptor is triggered by cholesterol depletion from the plasma membrane . . . . . 8125255 . . . . . . . . . . . . . Q9WVF5 . erbB . . . . . . . . . BAB23662 . . . . . . . . Q9WVF5 . . . . . . . . . . . . . . . . . . . MP:0002068 . . . . . . . AK054061 12836403 Q01279 12836404 . GO:0005489 IDA electron transporter activity . . Dephosphorylation of the EGFR and the consequent suppression of EGFR signalling. Review. . . . . . 11752569 . . . . . . . . . . . . . . . erbB . . . . . . . . . BAB23641 . . . . . . . . Q9EP98 . . . . . . . . . . . . . . . . . . . MP:0002134 . . . . . . . Z12608 26104387 CAA55587 567201 . GO:0006118 . electron transport . . EGF receptor signaling implicated in the daily control of locomotor activity . . . . . 12520078 . . . . . . . . . . . . . . . erbB . . . . . . . . . AAL56615 . . . . . . . . Q5SVE8 . . . . . . . . . . . . . . . . . . . MP:0002098 . . . . . . . AV369812 11055356 CAA42219 1352359 . GO:0008284 . positive regulation of cell proliferation . . Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase . . . . . 2030916 . . . . . . . . . . . . . . . erbB . . . . . . . . . AAH23729 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002076 . . . . . . . AK004944 11055358 AAA53029 12836512 . GO:0000902 . cellular morphogenesis . . The function and trafficking of the EGF receptor are modulated by cholesterol depletion in ways that serve to enhance EGF receptor signaling. . . . . . 11827542 . . . . . . . . . . . . . . . erbB . . . . . . . . . AAG43241 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002141 . . . . . . . AK004883 11055357 BAB23662 12836453 . GO:0007173 . epidermal growth factor receptor signaling pathway . . rotational dynamics . . . . . 10534613 . . . . . . . . . . . . . . . erbB . . . . . . . . . AAG28047 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002085 . . . . . . . S50854 458123 BAB23688 23271840 . GO:0004872 . receptor activity . . that a functional epidermal growth factor receptor [EGFR] appears to be indispensable for the adaptive response of the remnant intestine to massive small bowel resection . . . . . 12794006 . . . . . . . . . . . . . . . erbB . . . . . . . . . AAG28046 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002116 . . . . . . . U03425 4484962 AAK01081 12658303 . GO:0005622 . intracellular . . data are consistent with the regulation of EGFR by calmodulin at several steps of the receptor signaling and trafficking pathways . . . . . 12621152 . . . . . . . . . . . . . . . erbB . . . . . . . . . AAD44149 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002108 . . . . . . . AI552599 261582 AAA17899 488831 . GO:0016323 . basolateral plasma membrane . . dephosphorylation catalyzed by PTP1B required endocytosis and occurred at specific sites on the surface of the endoplasmic reticulum . . . . . 1459205 . . . . . . . . . . . . . . . erbB . . . . . . . . . CAI35984 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002113 . . . . . . . AF124513 261584 . . . GO:0008283 . cell proliferation . . The EGFR pathway is mechanistically important in responses of the embryo to TCDD . . . . . 12397069 . . . . . . . . . . . . . . . erbB . . . . . . . . . CAI24998 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002130 . . . . . . . S50853 23271839 . . . GO:0004714 . transmembrane receptor protein tyrosine kinase activity . . Activation of BAD by therapeutic inhibition and transactivation by insulin-like growth factor receptor . . . . . 12531698 . . . . . . . . . . . . . . . erbB . . . . . . . . . CAA55587 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002129 . . . . . . . AK004911 12836511 . . . GO:0000166 . nucleotide binding . . The data show that Gab1 plays an essential role in EGF-receptor/ErbB-mediated cell proliferation and oncogenesis. . . . . . 12058069 . . . . . . . . . . . . . . . erbB . . . . . . . . . AAG28045 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002135 . . . . . . . AF277898 261588 . . . GO:0016740 . transferase activity . . Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2 . . . . . 11872838 . . . . . . . . . . . . . . . erbB . . . . . . . . . AAG24386 . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002137 . . . . . . . AK014017 261586 . . . GO:0007165 . signal transduction . . STAT3 and STAT1 activation in HER14 cells was demonstrated to depend on EGF receptor kinase activity . . . . . 11274221 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002140 . . . . . . . BC030681 50805 . . . GO:0004871 . signal transducer activity . . Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the Nf1:p53 mouse tumor model. . . . . . 12154062 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002152 . . . . . . . X59698 26083410 . . . GO:0005768 . endosome . . Lysosomal sorting of kinase active EGFR is regulated by proteasomal activity. Immuno-EM showed the localization of intact EGFR on internal membranes of multi-vesicular bodies. . . . . . 11881154 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002096 . . . . . . . S50852 12851634 . . . GO:0007169 . transmembrane receptor protein tyrosine kinase signaling pathway . . These data implicate calcium-modulating cyclophilin ligand in epidermal growth factor [EGF] receptor signaling and suggest that it may play a role in receptor recycling during long-term proliferative responses to EGF. . . . . . 11076861 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002156 . . . . . . . S50855 193001 . . . GO:0005856 . cytoskeleton . . activated ErbB1; by endogenous or exogenous ligands; may protect the heart against stress-induced injury . . . . . 11841993 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002083 . . . . . . . AF275365 50803 . . . GO:0007166 . cell surface receptor linked signal transduction . . findings do not support a critical role for EGF or its receptor in chemotherapy-induced intestinal injury . . . . . 12477932 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002168 . . . . . . . AF275364 12836452 . . . GO:0016020 . membrane . . Bradykinin B2 receptor activates ERK1/2 in mIMCD-3 cells via transactivation of EGFR through a novel mechanism . . . . . 11910305 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002092 . . . . . . . AF275367 488830 . . . GO:0005886 . plasma membrane . . opposite cross-talk of AT1R and AT2R with EGF receptors . . . . . 12399441 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002089 . . . . . . . AF275366 12658302 . . . GO:0005524 . ATP binding . . A critical role for ras-mediated; epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis. . . . . . 12164862 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002086 . . . . . . . L06864 . . . . GO:0016301 . kinase activity . . results suggest that ligands of the epidermal growth factor receptor/erbB-1 and erbB-4 receptors regulate the lineage determination of islet cells during pancreatic development . . . . . 11823465 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002082 . . . . . . . . . . . . GO:0005515 . protein binding . . regulation of ligand availability by tumor necrosis factor-alpha converting enzyme . . . . . 12067982 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002081 . . . . . . . . . . . . GO:0016021 . integral to membrane . . A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells. . . . . . 11912208 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002128 . . . . . . . . . . . . GO:0005887 . integral to plasma membrane . . . . . . . . 12018405 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002127 . . . . . . . . . . . . GO:0006468 . protein amino acid phosphorylation . . . . . . . . 12466851 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002163 . . . . . . . . . . . . GO:0004713 . protein-tyrosine kinase activity . . . . . . . . 7678348 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002133 . . . . . . . . . . . . GO:0004672 . protein kinase activity . . . . . . . . 12069497 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002132 . . . . . . . . . . . . . . . . . . . . . . . 12676755 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002142 . . . . . . . . . . . . . . . . . . . . . . . 7764604 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002138 . . . . . . . . . . . . . . . . . . . . . . . 12808090 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002088 . . . . . . . . . . . . . . . . . . . . . . . 1408137 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002080 . . . . . . . . . . . . . . . . . . . . . . . 11865039 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002132 . . . . . . . . . . . . . . . . . . . . . . . 11864992 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002092 . . . . . . . . . . . . . . . . . . . . . . . 12919676 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002089 . . . . . . . . . . . . . . . . . . . . . . . 12162747 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002168 . . . . . . . . . . . . . . . . . . . . . . . 11161793 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002068 . . . . . . . . . . . . . . . . . . . . . . . 11217851 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002127 . . . . . . . . . . . . . . . . . . . . . . . 12629518 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002130 . . . . . . . . . . . . . . . . . . . . . . . 12011069 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002073 . . . . . . . . . . . . . . . . . . . . . . . 12604671 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002080 . . . . . . . . . . . . . . . . . . . . . . . 11042159 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002142 . . . . . . . . . . . . . . . . . . . . . . . 11919185 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002143 . . . . . . . . . . . . . . . . . . . . . . . 10349636 . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002108 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002138 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002129 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002156 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002113 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002135 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002074 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002086 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002163 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002128 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002140 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002081 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002133 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002082 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002093 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002095 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002076 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002098 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002085 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002083 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002141 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002152 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002134 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002088 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002096 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002137 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . erbB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002116 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . epidermal growth factor . . . . . . . . . . . . . . . . . . . . . 3 ENSMUSG00000028017 128688188 128610450 . NCBI Build 34 3 65.20 3 128688188 128610450 13645 . epidermal growth factor Egf Gene MGI:2139798 . 128688188 128610450 O P01132 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . epidermal growth factor . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65.2 . . . . . . . . MGI:95290 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EGF . . . . XM_287287 XP_287287 1418093_a_at Mouse430A_2 SP AAH92277 ENSMUSP00000067132 13645 Egf MGI:95290 Egf P01132 IPI00132121 NP_034243 Q8VD07 Mm.252481 UPI0000029938 3 ENSMUSG00000028017 128688188 128610450 . NCBI Build 34 3 65.20 3 128688188 128610450 319224 MGI:2441710 RIKEN cDNA 6330410L21 gene 6330410L21Rik Gene MGI:2139798 MP:0002094 128688188 128610450 O P01132 Low-density lipoprotein-receptor YWTD domain NT_039241.1 28545359 AK084927 17389247 P01132 17389248 13645 GO:0008083 IEA growth factor activity Obvious presence of granular duct cells in the sublingual glands of giant male mice suggests growth hormone-upregulated granular cell EGF expression AI790464 Egf up-regulates the transcription of ATP-dependent protease through extracellular signal-regulated protein kinase- and 1-phosphatidylinositol 3-kinase-dependent pathways. 3 G3 1950 RIKEN cDNA 6330410L21 gene Egf Mus musculus 15831470 30710222 30632484 NT_039240 64427894 NM_010113 6753731 NP_034243 6753732 PROVISIONAL 28545274 28545275 10090 Mm.252481 P01132 Egf EGF . . . . . . v00741_s_at Mu11KsubB . AAH17681 ENSMUSP00000029653 . . . . . . . Q569W5 . . . . . . . . . -1.00 . . . 13645 MGI:95290 epidermal growth factor Egf . MGI:2441710 MP:0002074 . . . . Calcium-binding EGF-like domain . . AK031828 1514608 AAH17681 309210 319224 GO:0050730 IGI regulation of peptidyl-tyrosine phosphorylation . . Absence of post-translational aspartyl beta-hydroxylation of domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia 3 65.2 cM 13645 epidermal growth factor 6330410L21Rik . 14712229 128688187 128610449 NC_000069 65492966 NM_010113 . NP_034243 . . 6753731 6753732 . Mm.1341 Q8VD07 . EGF . . . . . . . . . AAA37539 . . . . . . . . . . . . . . . . . . 65.2 . . . . MGI:95290 . . . MGI:95290 MP:0002073 . . . . . . . AK085707 26102917 CAA24115 50801 . GO:0008284 ISS positive regulation of cell proliferation . . Depletion of cholesterol from 3T3 cells enhances in vivo EGF-stimulated receptor autophosphorylation by 100-400% without affecting basal levels of receptor autophosphorylation. . 319224 . . . 15509736 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002143 . . . . . . . U69534 50800 AAA37539 119227 . GO:0001763 RCA branching morphogenesis . . in regenerating hepatocytes; several GST isoforms are induced and that cytokines TNFalpha and IL-6 and survival factor EGF positively regulate mGSTA4 via survival signaling pathways. . 99717 . . . 11940581 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002068 . . . . . . . AK088408 192993 . . . GO:0005509 IDA calcium ion binding . . role in stimulating ERK2 activation affecting vinexin beta regulation of anchorage dependence . . . . . 8240367 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002091 . . . . . . . X08047 26104795 . . . GO:0016020 . membrane . . EGF induces expression of early G[1] cyclins in mammary epithelial cells. . . . . . 14561752 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002134 . . . . . . . BC017681 1695887 . . . GO:0018108 . peptidyl-tyrosine phosphorylation . . Activation of m-calpain [calpain II] by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain. . . . . . 15314086 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002098 . . . . . . . J00380 26102338 . . . GO:0016021 . integral to membrane . . epidermal growth factor functions as a biologic switch that is turned on and off in hair follicles at the beginning and end of the anagen phase of the hair cycle; guarding the entry to and exit from the anagen phase . . . . . 12714603 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002141 . . . . . . . V00741 26082543 . . . GO:0005615 . extracellular space . . Egf inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xl upregulation in mammary epithelial cells. . . . . . 6304537 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002137 . . . . . . . . . . . . . . . . . findings do not support a critical role for EGF or its receptor in chemotherapy-induced intestinal injury . . . . . 11825889 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002131 . . . . . . . . . . . . . . . . . EGF causes cultured SVZ cells to form multipotent and self-renewing neurospheres. These EGF-responsive cells are not derived from quiescent stem cells; but from the highly mitotic; Dlx2[+]; transit-amplifying C cells. . . . . . 8940071 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002096 . . . . . . . . . . . . . . . . . . . . . . . 11076861 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002169 . . . . . . . . . . . . . . . . . . . . . . . 11841993 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002168 . . . . . . . . . . . . . . . . . . . . . . . 12477932 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002092 . . . . . . . . . . . . . . . . . . . . . . . 12837294 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002089 . . . . . . . . . . . . . . . . . . . . . . . 11956170 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002162 . . . . . . . . . . . . . . . . . . . . . . . 12466851 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002092 . . . . . . . . . . . . . . . . . . . . . . . 11773073 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002094 . . . . . . . . . . . . . . . . . . . . . . . 11884396 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002089 . . . . . . . . . . . . . . . . . . . . . . . 11909964 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002168 . . . . . . . . . . . . . . . . . . . . . . . 3076779 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002068 . . . . . . . . . . . . . . . . . . . . . . . 6602382 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002073 . . . . . . . . . . . . . . . . . . . . . . . 12495619 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002131 . . . . . . . . . . . . . . . . . . . . . . . 12162747 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002169 . . . . . . . . . . . . . . . . . . . . . . . 11217851 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002143 . . . . . . . . . . . . . . . . . . . . . . . 12372343 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002091 . . . . . . . . . . . . . . . . . . . . . . . 11042159 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002074 . . . . . . . . . . . . . . . . . . . . . . . 10349636 . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002162 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002098 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002141 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002134 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002096 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EGF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MP:0002137 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . apolipoprotein E . . . . . . . . . . . . . . . . . . . . . 7 ENSMUSG00000002985 16568297 16565518 . NCBI Build 34 7 4.00 7 16568277 16565517 11816 . apolipoprotein E Apoe Gene MGI:2141887 . 16568297 16565518 O P08226 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . apolipoprotein E . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4.0 . . . . . . . . MGI:88057 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .